Complete PCOS Savings Bundle
- Reduces Insulin Resistance
- Reduces Testosterone Levels
- Aids In Weight Loss
- Improves Hirsutism
- Improves Natural Ovulation Rates
Inositol is a naturally occurring sugar found in foods such as fruits (especially citrus fruits), beans, grains, and nuts. Your body can also make inositol from the carbohydrates you eat in your diet. In saying this, to achieve 3-4g daily of inositol a supplement will most likely be required.
It’s by far the most well-researched supplement in regards to PCOS with the amount of research and population within the studies quite extensive now. Its main mechanism of action for PCOS is its ability to improve insulin sensitivity although it is used outside. It's sometimes used during IVF due to its ability to improve ovarian function, oocyte quality, embryo, and pregnancy rates and reduce gonadotropin amount during stimulation.
In PCOS-specific studies, benefits have included:
- Improves ovulation rates
- Decreases insulin levels
- Decreases testosterone levels
- Improves LH / FSH ratio (this is one-way inositol can aid in improved menstrual regulation)
- Aids in weight loss
- Increases SHBG levels (likely to play a role in inositol's ability to lower testosterone levels as increased SHBG = decreased free testosterone).
Thermo Lean is our potent thermogenic fat burner which combines a specific blend of proven ingredients to help maximize your fat-burning potential effectively and safely. Our proprietary blend is designed to elevate metabolic burn and increase energy and motivation levels.
Thermo Lean is PCOS friendly due to its unique blend of ingredients that help to improve the PCOS hormonal state. The blend of ingredients works synergistically to offer you an advanced approach to fat burning by increasing your fat metabolism, boosting energy levels, and supporting optimal mental performance and moods.
N-acetyl-cysteine (NAC) is the acylated form of L-cysteine amino acid and also one of the precursors of glutathione, an antioxidant substance.
Cysteine is a semi-essential amino acid. It’s considered semi-essential because your body can produce it from other amino acids, namely methionine, and serine. It becomes essential only when the dietary intake of methionine and serine is low. Cysteine is found in most high-protein foods, such as chicken, turkey, yogurt, cheese, eggs, sunflower seeds, and legumes. N-acetyl cysteine (NAC) is a supplement form of cysteine.
Spearmint is a type of mint that originally was found in Asia and Europe. It’s often used to flavour foods, mouthwash, toothpaste, and chewing gum but, did you know that brewed as a tea, spearmint has some potentially wonderful benefits for those with PCOS.
One study found that drinking two cups of spearmint tea had significant anti-androgen effects for women with PCOS. For the women who participated in the study, Free and total testosterone levels were significantly reduced, LH and FSH also increased. The women’s subjective (self-assessed) assessments of their degree of hirsutism were significantly reduced in the spearmint tea group. Other studies have also found that spearmint tea may also help to improve follicular development and ovulation.
Interestingly as well, a study looking into the combination of spearmint tea and flaxseeds found that this combination may help at reducing testosterone levels, increasing progesterone levels, and improving follicle counts in the ovary. Although more research is needed to definitely find the benefits and underlying mechanisms, spearmint tea is generally quite a safe and relatively cheap drink that is easy to incorporate into your daily life, it’s also caffeine and calorie-free.
It's also interesting because although the total amount of research behind it is quite small compared to other supplements, the overall feedback I see from customers is probably one of the most positive out of everything.
Berberine is a compound in several plants, including goldenseal, barberry, Oregon grape, and tree turmeric that has been a part of Chinese and Ayurvedic medicine for thousands of years. Many studies of berberine have indicated that it can treat several metabolic health conditions, including diabetes, obesity, and heart problems.
A clinical trial compared metformin use and NAC over a 24-week period. Both groups had equal results in terms of decreased BMI and free testosterone levels, improved insulin sensitivity, menstrual cyclicity, and lower hirsutism scores
Other known benefits of NAC include:
- NAC is needed to make and replenish glutathione, one of the body’s most important antioxidants, which helps neutralize free radicals that can damage cells and tissues in your body.
- By helping replenish the antioxidant glutathione and regulate glutamate, NAC helps promote optimal brain health
- Improve insulin sensitivity and reduce inflammation in fat cells.
- Induced a redistribution of adipose tissue(body fat), reducing VAT (mid-section fat) even in the absence of weight loss.
- Improved insulin sensitivity, quite like metformin
- Improved ovulation rates per cycle
- Is effective on fertility and live birth rates
- Supplementation showed few side effects
A 2020 systematic review (PMC7028834) titled "Polycystic ovary syndrome management: a review of the possible amazing role of berberine" in PCOS treatment of over 1,000 PCOS women found that Berberine:
Efficacy of myo-inositol for improving insulin sensitivity in women with PCOS
Taken from Gynecological Endocrinology -- we investigated the efficacy on insulin sensitivity and hormonal parameters of 8 weeks treatment with myo-inositol at the dosage of 2g per day in a group of obese PCOS patients. After the treatment interval, body mass index (BMI) and insulin resistance decreased together with luteinizing hormone (LH), LH/FSH and insulin.
Inositol and ovulation frequency in women with PCOS
Taken from European review for medical and pharmacological sciences -- A total of 283 women with PCOS were randomised in two groups, receiving either inositol or placebo. The analysis revealed that 94% of women in the inositol-treated group successfully ovulated whereas 87% of women ovulated in the placebo group. In summary, the inositol-treated group had a significantly increased frequency of ovulation compared with the placebo group.
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